ANHYDROTETRACYCLINE HYDROCHLORIDE CAS 13803-65-1
Product description
Product Detail
Description
ANHYDROTETRACYCLINE HYDROCHLORIDE QUICK DETAILS
Chemical Name: ANHYDROTETRACYCLINE HYDROCHLORIDE
CAS No.: 13803-65-1
Molecular Formula: C22H23ClN2O7
Molecular Weight: 462.88
ANHYDROTETRACYCLINE HYDROCHLORIDE Chemical Properties
| Melting point | 223 °C |
| RTECS | QI7860000 |
| storage temp. | Refrigerator |
| solubility | Soluble in ethanol, DMSO, or DMF |
| form | Powder |
| color | Yellow to bright yellow |
| Sensitive | Moisture Sensitive |
| BRN | 4228856 |
| Stability | Hygroscopic |
| EPA Substance Registry System | 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-, hydrochloride (1:1), (4S,4aS,12aS)- (13803-65-1) |
ANHYDROTETRACYCLINE HYDROCHLORIDE Chemical Properties,Uses
Description
The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression. Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription. Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet. Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet, so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.
Chemical Properties
yellow to bright yellow powder
Uses
A Tetracycline derivative exhibiting no antibiotic activity, a useful effector of tetracycline-dependent gene expression in bacterial expression systems.
Anhydrotetracycline is a degradation product of tetracycline, formed by dehydration at the C6 position under acidic conditions to aromatise the B ring. Anhydrotetracycline is an important standard for monitoring tetracycline stability. Although the degradation is associated with a loss of antibiotic activity, anhydrotetracycline is considered biologically active and is thought responsible for aspects of tetracycline toxicity.
Anhydrotetracycline hydrochloride is a salt of a degradation product of tetracycline, formed by dehydration at the C6 position under acidic conditions to aromatise the B ring. Anhydrotetracycline is an important standard for monitoring tetracycline stability. Although the degradation is associated with a loss of antibiotic activity, anhydrotetracycline is considered biologically active and is thought responsible for aspects of tetracycline toxicity.